JUNG, Michael E.,SAWYERS, Charles L.,OUK, Samedy,TRAN, Chris,WONGVIPAT, John
申请号：
ES07754060
公开号：
ES2564388T3
申请日:
2007.03.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to formula II: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein Het is selected from the group consisting of: ** Formula ** wherein R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkyl, arylalkyl, halogenated alkyl, halogenated alkenyl, halogenated alkynyl, halogen, CN, NO2, OR11, SR11, NR11R12, NH (CO) OR11, NH (CO) NR11R12, NR12 (CO) R11, O (CO) R11, O (CO) OR11, O (CS) R11, NR12 (CS) R11, NH (CS) NR11R12, and NR12 (CS) OR11, wherein any of R4, R5, R6 and R7 may be attached to an adjacent R4, R5, R6 and R7 to form a cycle that may be aromatic, aromatic substituted, aromatic or non-aromatic heterocyclic, aromatic or non-aromatic substituted heterocyclic, cycloalkyl or substituted cycloalkyl, wherein X is selected from sulfur, oxygen and N R8, and wherein R8 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkenyl, arylalkyl, halogenated alkyl, halogenated alkenyl, halogenated alkynyl, halogen, (CO) R11, (CO) OR11, (CS) R11 and (CS) OR11； and where: A is sulfur and B is oxygen； R11 and R12 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkenyl, arylalkyl, heterocyclic aromatic or non-aromatic compound, or heterocyclic aromatic or non-aromatic compound substituted, or R11 and R12 may be linked to form a cycle that may be aromatic or non-aromatic heterocyclic, or substituted heterocyclic aromatic, R1 is selected from aryl and substituted aryl, R2 and R3 are independently selected from hydrogen, aryl, alkyl , substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogenated alkyl, halogenated alkeny
