Jung, Michael E,Sawyers, Charles L,Ouk, Samedy,Tran, Chris,Wongvipat, John
申请号：
ES13178047
公开号：
ES2593379T3
申请日:
2007.03.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to formula II: ** Formula ** or a pharmaceutically acceptable salt thereof, in which Het comprises: (a) a heterocyclic unit of 6 atoms, wherein the heterocyclic unit comprises 1 or 2 selected heteroatoms regardless of the group consisting of nitrogen, oxygen or sulfur, in which Het comprises 0 or 1 substituent linked with double bond in the heterocyclic unit selected from the group consisting of oxygen and sulfur: in which Het comprises 4 or 3 substituents linked with single bond in the heterocyclic unit selected from the group consisting of hydrogen, halogenated alkyl, CN, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkyl, arylalkyl, halogenated alkenyl, alkynyl halogenated, halogen, NO2, OR11, SR11, NR11R12, NH (CO) OR11, NH (CO) NR11R12, NR12 (CO) R11, O (CO) R11, O (CO) OR11, O (CS) R11, NR12 ( CS) R11, NH ( CS) NR11R12, NR12 (CS) OR11； or (b) a heterocyclic unit of 5 atoms, wherein the heterocyclic unit comprises 1 or 2 heteroatoms independently selected from the group consisting of sulfur, oxygen, nitrogen and NR8, wherein R8 is selected from the group consisting of hydrogen , alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkenyl, arylalkyl, halogenated alkyl, halogenated alkenyl, halogen, (CO) R11, (CO) OR11, (CS) R11, (CS) OR11, wherein Het comprises from 2 to 3 single bond linked substituents in the heterocyclic unit selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, aryl substituted, arylalkyl, arylalkenyl, arylalkyl, halogenated alkyl, halogenated alkenyl, halogenated alkynyl, halogen, CN, NO2, OR11, SR11, NR11R12, NH (CO) OR11, NH (CO) NR11R12, NR12 (CO) R11, O (CO) R11, O (CO) OR11, O (CS) R11, NR12 (CS) R11, NH (CS) NR11R12, NR12 (CS) OR11, in which A and B are independently selected fro
