KIM, Ki Woon,김기운,LEE, Seung Hoo,이승후,JEONG, Sook In,정숙인
申请号：
KRKR2014/001931
公开号：
WO2014/157851A1
申请日:
2014.03.10
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention provides an eperisone pharmaceutical composition having improved preservability and pH stability, the composition containing 20-60 wt% of eperisone or a pharmaceutically acceptable salt thereof 1-30 wt% of at least one acidifier selected from D-glucaric acid, D-glucoascorbic acid, gluconic acid, D-glucuronic acid, gluconolactone, glucuronolactone, glutamic acid, itaconic acid, caffeic acid, glycyrrhizic acid, ethane sulfonic acid, benzene sulfonic acid, dehydroascoribic acid, salicylic acid, salicyl sulfonic acid, gallic acid, nicotinic acid, and chlorogenic acid 0.3-8 wt% of a binder and 10-80 wt% of a diluent.La présente invention porte sur une composition pharmaceutique dépérisone ayant une conservabilité et une stabilité au pH améliorées, la composition contenant 20-60 % en poids dépérisone ou dun sel pharmaceutiquement acceptable dépérisone 1-30 % en poids dau moins un acidifiant choisi parmi lacide D-glucarique, lacide D-glucoascorbique, lacide gluconique, lacide D-glucuronique, la gluconolactone, la glucuronolactone, lacide glutamique, lacide itaconique, lacide caféique, lacide glycyrrhizique, lacide éthanesulfonique, lacide benzènesulfonique, lacide déhydroascorbique, lacide salicylique, lacide salicylsulfonique, lacide gallique, lacide nicotinique et lacide chlorogénique 0,3-8 % en poids dun liant et 10-80 % en poids dun diluant.본 발명은 에페리손 또는 그의 약제학적으로 허용 가능한 염 20∼60 중량% D-글루카르산, D-글루코아스코르브산, 글루콘산, D-글루쿠론산, 글루코노락톤, 글루쿠로노락톤, 글루탐산, 이타콘산, 카페인산, 글리시리진산, 에탄술폰산, 벤젠술폰산, 데하이드로아스코르브산, 살리실산, 살리실술폰산, 몰식자산, 니코틴산 또는 클로로겐산에서 선택된 1종 이상의 산성화제 1∼30 중량% 결합제 0.3∼8 중량% 및 희석제 10∼80 중량%를 포함하는 저장 및 pH 안정성이 개선된 에페리손 의약조성물을 제공하는 것이다.
