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UTILIZAÇÃO DE DERIVADOS DE TIOFLAVINA RADIOROTULADOS EM IMAGIOLOGIA AMILOIDE PARA AVALIAR TERAPIAS ANTI-AMILOIDE
专利权人:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
WILLIAM E. KLUNK,CHESTER A. MATHIS
申请号:
PT05787557
公开号:
PT1771208E
申请日:
2005.07.01
申请国别(地区):
PT
年份:
2013
代理人:
摘要:
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.
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