A lipid membrane structure can be efficiently deliver nucleic acid into the nucleus of immune cells, such as dendritic cells, polypeptides and a lipid membrane comprising the amino acid sequence described below in (a) SEQ ID NO: 1 / or a polypeptide consisting of an amino acid sequence that has been inserted and / or substituted deletions and / or of one or several amino acids in the amino acid sequence set forth in (b) SEQ ID NO: 1, into the nucleus of cells lipid membrane structure for delivering a substance into the cell nucleus that is modified with a polypeptide having the activity of promoting the migration of the lipid membrane structure.樹状細胞などの免疫細胞の核内に核酸を効率的に送達することができる脂質膜構造体であって、脂質膜が下記の(a)配列番号1に記載のアミノ酸配列からなるポリペプチド及び/又は(b)配列番号1に記載のアミノ酸配列において1個又は数個のアミノ酸が欠失及び/又は置換及び/又は挿入されたアミノ酸配列からなるポリペプチドであって、細胞の核内への脂質膜構造体の移行を促進する活性を有するポリペプチドで修飾された細胞核内に物質を送達するための脂質膜構造体。
