NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人:
HARASHIMA, HIDEYOSHI,AKITA, HIDETAKA,SHARIF, MOHAMMAD SHAHEEN,NAKAMURA, TAKASHI,ISHII, SOICHIRO,FUTAKI, SHIROH
申请号：
EP11772046
公开号：
EP2572706A4
申请日:
2011.04.20
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.
