DEFAUW, JEAN MARIE,HOLMSTROM, SCOTT DALE,CHEN, SHUHUI,ZHANG, YANG,WU, WEN-TAO,PENG, XIAN,MA, YU-JUAN,LU, LUN
申请号：
TW101101513
公开号：
TW201242930A
申请日:
2012.01.13
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Provided are compounds, and salts thereof, of formula I: wherein A is R1 is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C5 alkanol, -(C1-C5 alkyl)phenyl, or phenyl, or a group of the formula -C(O)-R12, where R12 may be C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C5 alkanol, -(C1-C5 alkyl)phenyl, or phenyl R2 and R3 are independently hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, C1-C5 haloalkyl, or C1-C5 haloalkoxy R4 and R5 are independently hydrogen, C1-C5 alkyl, or -(C1-C5 alkyl)phenyl R6 is hydrogen, hydroxy, or is absent R7 is hydrogen R8 and R9 are independently hydrogen or methyl R10 is hydrogen R11 is hydrogen or C1-C5 alkyl or R7 and R10 combine to form -CH2- or -(CH2)2- or R8 and R9 combine to form a cyclopropyl group with the carbon to which they are attached or R10 and R11 combine to form -CH2- or -(CH2)3-. Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.
