ST. JOHN, JOHN V.,约翰 圣约翰,約翰 聖約翰,MORO, DANIEL G.,丹尼尔 摩洛,丹尼爾 摩洛,约翰 圣约翰,約翰 聖約翰,丹尼尔 摩洛,丹尼爾 摩洛
申请号：
TW096137843
公开号：
TWI563987B
申请日:
2007.10.09
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalescein situinto the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissuein vivoto form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.本發明關於生成外形保持性(shape－retentive)及外形配合性(shape－conforming)凝聚團塊之傷口敷料及生物性材料(其係由膠質奈米顆粒及傷口或體液所組成)之方法，其中藉由非共價鍵物理力(諸如但不限於厭水性－親水性交互作用及氫鍵)使該凝聚團塊保持凝聚。該方法包含導入膠質奈米顆粒之乾燥粉末至傷口部位，其中該奈米顆粒吸收一些血液或傷口滲出物並於原位凝結成所請之外形保持性凝聚團塊敷料。該方法亦包含導入該乾燥奈米顆粒粉末於活體濕身體組織內或之上以生成所請之外形保持性生物性材料。此外，該方法亦包含併入生醫藥劑以產生供各種醫療應用的藥用凝聚團塊敷料或生物性材料。本發明亦關於生成該膠質奈米顆粒之外形保持性凝聚團塊之方法的應用。
