The present invention provides a method for treating or preventing heart failure with preserved ejection fraction (HFPEF), wherein the method comprises administering to a patient having or at risk of developing HFPEF a therapeutically effective amount of imeglimin.本發明提供用於治療或預防正常射血分率心臟衰竭(HFPEF)之方法,其中該方法包含投予患有HFPEF或處於發展出HFPEF之風險的患者治療有效量之伊美利敏(imeglimin)。