LIU, DEAN MO,刘典谟,劉典謨,TUNG, TSAN HUA,董簪华,董簪華,CHENG, HONGWEI,程洪伟,程洪偉
申请号：
TW099144446
公开号：
TWI400088B
申请日:
2010.12.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention discloses the synthesis of a new-type chitosan-based hybrid macromolecule and a method for producing or using themacromolecule. This macromolecule comprises an amphiphatic chitosan and a silicon-based coupling agent that is anchored by a chemical bonding. The method for producing the hybrid macromolecule can be easily operated under ambient environment. The produced macromolecule can be self-assembled in an aqueous environment to form a nanocarrier, and has the ability to efficiently encapsulate drugs for a subsequent sustained release purpose. This self-assembled hybrid nanocarrier demonstrated features of excellent biocompatibility, drug loading ability and cellular uptake efficiency.本發明係一種藥物載體原料及其製造方法和使用方法,藥物載體原料係以化學鍵結的方式結合有具抗菌效果的改質有機幾丁聚醣和具有矽烷基的無機偶聯劑,本發明的藥物載體原料製造方法十分簡單,所形成的藥物載體原料可以在水溶液進行自組裝以包覆藥物,並可適用於多種藥物之包覆,亦具有生物相容性佳、藥物包覆率高和細胞吸收率良好之優點。I...碳骨架II...羧基改質親水端III...長鏈碳基改質疏水端
