ANDRIES, KOENRAAD JOZEF LODEWIJK MARCEL,KOUL, ANIL,GUILLEMONT, JEROME EMILE GEORGES,PASQUIER, ELISABETH THERESE JEANNE
申请号：
CA2528849
公开号：
CA2528849C
申请日:
2005.12.06
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, Ar or Het； p is an integer equal to 1 or 2； R2 is C1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy or C1-6alkylthio； R3 is Ar, Het or Het1； R4 and R5 each independently are hydrogen, C1-6alkyl or benzyl； or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with C1- 6alkyl, halo, polyhaloC1-6alkyl, hydroxy, hydroxyC1-6alkyl, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, C1-6alkylthioC1- 6alkyl or pyrimidinyl； R6 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio； or two vicinal R6 radicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH- ； r is an integer equal to 1 or 2； R7 is hydrogen, C1-6alkyl, Ar, Het or Het1； provided that the bacterial infection is other than a Mycobacterial infection.
