ANDRIES, KOENRAAD JOZEF LODEWIJK MARCEL,KOUL, ANIL,GUILLEMONT, JEROME EMILE GEORGES,PASQUIER, ELISABETH THERESE JEANNE,LANCOIS, DAVID FRANCIS ALAIN
申请号：
CA2615901
公开号：
CA2615901C
申请日:
2006.07.31
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Use of a compound for the manufacture of a medicament for the treatment of abacterial infection provided that the bacterial infection is other than aMycobacterial infection, said compound being a compound of Formula (Ia) or(Ib), a pharmaceutically acceptable acid or base addition salt thereof, aquaternary amine thereof, a stereochemically isomeric form thereof, atautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen,halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio,alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl； p is 1, 2 or 3； R2 ishydrogen； alkyl； hydroxy； mercapto； optionally substituted alkyloxy；alkyloxyalkyloxy； alkylthio； mono or di(alkyl)amino wherein alkyl mayoptionally be substituted； Ar； Het or a radical of Formula (.IOTA..IOTA.)； R3is alkyl, Ar, Ar-alkyl, Het or Het-alkyl； q is zero, 1, 2, 3 or 4； X is adirect bond or CH2； R4 and R5 each independently are hydrogen, alkyl orbenzyl； or R4 and R5 may be taken together including the N to which they areattached； R6 is hydrogen or a radical of Formula (III)； R7 is hydrogen, alkyl,Ar or Het； R8 is hydrogen or alkyl； R9 is oxo ； or R8 and R9 together form theradical -CH=CH-N=.
