MUTATED TRUNCATED VON WILLEBRAND FACTOR

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专利权人:

发明人:

ANDREWS ARNA,PANOUSIS CON,EMMRICH KERSTIN,WILSON MICHAEL,DOWER STEVE,HARDY MATTHEW,HARTMAN DALLAS

申请号：

IN201847029054

公开号：

IN201847029054A

申请日:

2018.08.02

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

MUTATED TRUNCATED VON WILLEBRAND FACTOR The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least one modification at a position selected from the group consisting of L18, V42, K149, N248, S279, V320, T325, Q395 and K418 such that the modified polypeptide binds to Factor VIII with an off rate lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.

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