MUTATED VON WILLEBRAND FACTOR

• 收藏
• 分享

专利权人:

CSL BEHRING RECOMBINANT FACILITY AG

发明人:

ANDREWS, ARNA,PANOUSIS, CON,EMMRICH, KERSTIN,WILSON, MICHAEL,DOWER, STEVE,HARDY, MATTHEW,HARTMAN, DALLAS

申请号：

CA3008448

公开号：

CA3008448A1

申请日:

2017.01.06

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least one modification at a position selected from the group consisting of L18, V42, K149, N248, S279, V320, T325, Q395 and K418 such that the modified polypeptide binds to Factor VIII with an off rate lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/