A method of managing pain using neurophysiological data acquired from the brain of a subject is disclosed. The method comprises: identifying activity-related features in the data； parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain； comparing at least some of the defined capsules to at least one reference capsule； and assessing the likelihood that the subject is experiencing pain responsively to the comparison.
