Disclosed is a medicine discharge device of an automatic medicine packing machine, which is used to discharge a medicine, fed from a medicine cassette based on a medical prescription, into a medicine packing device. The medicine discharge device includes a medicine input unit (40) installed under a medicine cassette mount to receive the medicine fed from the medicine cassette, a frame (10) provided with a gate unit, the gate unit including gate members (11a,11b) to be opened or closed by a drive unit (13,14) so as to control movement of the medicine discharged from the medicine input unit (40), a plate (22) installed under the frame (10) and having an accommodation portion to receive the medicine and a recess (24) to allow the medicine to be moved from the gate members (11a,11b) to a discharge passage (19), a vibrator (21) to vibrate the plate (22), and a medicine transfer unit to discharge the medicine, having passed through the recess (24), into a hopper (130).
