PROBLEM TO BE SOLVED: To provide a hardly water-soluble medical agent-containing skin care sheet which contains a hardly water-soluble medical agent, can improve a skin function without causing cloudiness, can wipe stain with weak irritation, achieves both of a refreshing feeling and no sticky feeling upon wiping, and does not cause white leavings upon wiping.SOLUTION: The hardly water-soluble medical agent-containing skin care sheet is obtained by impregnating a water absorptive non-woven fabric with a hardly water-soluble medical agent-containing composition, and the hardly water-soluble medical agent-containing composition is a clear soluble medical agent at least including a hardly water-soluble medical agent whose content in the hardly water-soluble medical agent-containing composition is ≥1 mass%, a nonionic surfactant having an HLB of ≥10, ethanol and polyhydric alcohol, and the containing ratio between the ethanol and the polyhydric alcohol is (0.05/1) to (6/1), and the containing ratio between the hardly water-soluble medical agent and the nonionic surfactant is (0.2/1) to (20/1).COPYRIGHT: (C)2013,JPO&INPIT【課題】難水溶性薬剤を含み、白濁が生じることなく皮膚機能を改善でき、患部に対し弱い刺激で汚れを拭取ることができ、拭取り時のさっぱり感とベタツキ感のなさとを両立し、拭取り時に白残りが生じることのない難水溶性薬剤含有皮膚用シートの提供。【解決手段】本発明の難水溶性薬剤含有皮膚用シートは、難水溶性薬剤含有組成物を、吸水性不織布に含浸させた難水溶性薬剤含有皮膚用シートであって、前記難水溶性薬剤含有組成物が、少なくとも前記難水溶性薬剤含有組成物における含有量が1質量%以上である難水溶性薬剤、HLBが10以上であるノニオン性界面活性剤、エタノール、及び多価アルコールを含む澄明な可溶化組成物であり、前記エタノールと前記多価アルコールとの含有比が0.05/1~6/1であり、前記難水溶性薬剤と前記ノニオン性界面活性剤との含有比が0.2/1~20/1である。【選択図】なし