PAEK, SEUNG YUP,白承烨,白承燁,LEE, SUNG BAE,李成培,PARK, DEOK SEONG,朴德星,LEE, WON HYUNG,李沅炯
申请号：
TW103105447
公开号：
TW201444794A
申请日:
2014.02.19
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates tonovel compoundsof Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders. wherein, R1, R2, X, W, QandS are as defined herein.本發明係關於一種作為鞘氨醇-1-磷酸酯受體促效劑之式1新穎化合物，其可有效用於治療自體免疫疾病，一種製備該化合物之方法，以及一種包含該化合物做為活性成分之醫藥組成物。根據本發明之化合物對於廣泛自體免疫疾病及慢性發炎疾病有效，慢性發炎疾病包括復發-緩解型多發性硬化症，該化合物也可用於治療或預防免疫調節疾患。其中，R1,R2,X,W,Q及S如文中所定義。
