Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a sphingosine-1-phosphate receptor agonist active agent in combination with a topical delivery vehicle, e.g., a topical patch that includes an adhesive layer and a backing layer. Also provided are methods of topically delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat a subject for a disease condition, such as an immune system disorder like multiple sclerosis, a hyperproliferative dermatological disorder, e.g., psoriasis, acne, etc. Packaged topical formulations, kits including such formulations, and methods of making such formulations are also provided.本發明提供局部鞘胺醇-1-磷酸酯受體激動劑活性劑調配物。經皮調配物之態樣包括鞘胺醇-1-磷酸酯受體激動劑活性劑量與局部遞送媒介(例如，包括黏著層及背襯層的局部貼片)之組合。亦提供局部遞送治療有效量的鞘胺醇-1-磷酸酯受體激動劑活性劑予個體之方法，例如以治療個體的疾病症狀，諸如免疫系統病症(如多發性硬化症)、過度增生性皮膚學病症(例如，牛皮癬)、痤瘡等等。亦提供包裝之局部調配物、包括該等調配物之套組及製造該等調配物之方法。
