Iontophoretic devices for transdermal delivery of a sphingosine-1-phosphate receptor agonist active agent are provided. Also provided are methods of transdermally delivering a therapeutically effective amount of a sphingosine-1-phosphate receptor agonist active agent to a subject, e.g., to treat immune system disorders such as multiple sclerosis. Packaged iontophoretic systems, kits including iontophoretic devices, and methods of making iontophoretic devices are also provided.提供經皮膚傳輸鞘氨醇-1-磷酸鹽受體促效劑活性劑用的離子導入裝置。亦提供經皮膚傳輸方法將有療效劑量之鞘氨醇-1-磷酸鹽受體促效劑活性劑經皮膚傳輸至患者以例如如治療免疫系統障礙如多發性硬化症的經皮膚傳輸方法。亦提供經包裝的離子導入系統、包含離子導入裝置之套件及離子導入裝置之製造方法。
