BONDY, Steven,CANNIZZARO, Carina,CHOU, Chien-Hung,LINK, John,LIU, Qui,SCHROEDER, Scott,TSE, Winston,ZHANG, Jennifer
申请号：
ES14705605
公开号：
ES2614053T3
申请日:
2014.01.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula I: ** ** Formula wherein: A is a N-5-membered heteroaryl, wherein the N-5-membered heteroaryl is substituted with a group Z1 and optionally substituted with one or more Z2 groups R1 is a bicyclic or tricyclic heteroaryl heteroaryl, wherein any bicyclic heteroaryl, or tricyclic heteroaryl of R1 is optionally substituted with one or more groups Z3 R2 is a phenyl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any phenyl, heteroaryl members or 6-membered heteroaryl of R2 is optionally substituted with one or more Z4 groups Z1 is selected from alkyl (C3-C8), aryl, heteroaryl, heterocycle and aryl (C1-C6) -, wherein any aryl, heteroaryl, heterocycle and aryl (C1-C6) - Z1 is optionally substituted with one or more Z1a or Z1b groups and wherein any alkyl (C3-C8) Z1 is optionally substituted with one or more groups Z1a Z1a is each independently selected from carbocycle (C3-C7), halogen, -CN, -ORn1, -OC (O) Rp1, -OC (O) NRq1Rr1, -SRn1, -S (O) Rp1, -S (O ) 2OH, -S (O) 2Rp1, -S (O) 2NRq1Rr1, -NRq1Rr1, -NRn1CORp1, -NRn1CO2Rp1, -NRn1CONRq1Rr1, -NRn1S (O) 2Rp1, -NRn1S (O) 2ORp1, -NRn1S (O) 2NRq1Rr1, NO2, -C (O) Rn1, -C (O) ORn1 and -C (O) NRq1Rr1 each Z 1b is independently selected from alkyl (C1-C6) and carbocyclic (C3-C5) wherein any (C1-C6) and carbocyclic (C3-C5) Z1b is optionally substituted with one or more halogens each Z2 is independently selected from alkyl (C1-C3), (C1-C3), halogen and -O (C1-C3) each Z3 is independently selected from alkyl (C1-C6) carbocycle (C3-C7), halogen, -CN, -ORn2, -OC (O) Rp2, -OC (O) NRq2Rr2, -SRn2, -S (O ) Rp2, -S (O) 2OH, -S (O) 2Rp2, -S (O) 2 NRq2Rr2, -NRq2Rr2, -NRn2CORp2, -NRn2CO2Rp2, -NRn2CONRq2Rr2, -NRn2S (O) 2Rp2, -NRn2S (O) 2ORp2 , -NRn2S (O) 2NRq2Rr2, NO2, -C (O) Rn2, -C (O) ORn2 and -C (O) NRq2Rr2 wherein any carbocycle (C3-C7) alkyl and (C1-C6) Z3 It is optionally substituted with one or more halogens each Z4 is independently selected from alkyl (C1-C6), halogen and -ORn3, wherein any (C1-C6) Z4 is option
