COMPLEXES METALLIQUES AVEC DU BISPHOSPHONATE OU DU PYROPHOSPHATE UTILES EN TANT QU'AGENTS D'IMAGERIE

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专利权人:

DUKE UNIVERSITY

发明人:

LASCOLA, CHRISTOPHER DAVID

申请号：

CA2983829

公开号：

CA2983829A1

申请日:

2016.04.22

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y - X - Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.

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