BAO, JIANMING,包 奖明,包 獎明,GAO, XIAOLEI,高 孝雷,KNOWLES, SANDRA LEE,诺里斯 珊卓 李,諾里斯 珊卓 李,LI, CHUNSING,李淳兴,李淳興,LO, MICHAEL MAN-CHU,卢 文柱,盧 文柱,MAZZOLA, ROBERT D., JR.,马兹拉 罗伯 Ｄ 二世,馬茲拉 羅伯 Ｄ 二世,L ONDEYKA, DEBRA,包 奖明,包 獎明,高 孝雷,诺里斯 珊卓 李,諾里斯 珊卓 李,卢 文柱,盧 文柱,马兹拉 罗伯 D 二世,馬茲拉 羅伯 D 二世
申请号：
TW105142474
公开号：
TW201726675A
申请日:
2016.12.21
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological psychiatric disorders diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.本發明係關於6,7-二氫-5H-吡咯并[3,4-b]吡啶-5-酮化合物，其為M4蕈毒鹼乙醯膽鹼受體之異位調節劑。本發明亦關於本文所述化合物在與M4蕈毒鹼乙醯膽鹼受體有關之神經及精神病症及疾病之潛在治療或預防中的用途。本發明亦關於包含此等化合物之組合物。本發明亦關於此等組合物在此類與M4蕈毒鹼乙醯膽鹼受體有關之疾病之潛在預防或治療中的用途。
