UNIVERSITY OF MARYLAND, BALTIMORE;NORTHWESTERN UNIVERSITY;ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO
发明人:
KAUSHAL, SUNJAY,HO, DEAN,ROBINSON, ERIK M.,MCCARTHY, PATRICK M.
申请号：
EP14800460
公开号：
EP2999427A4
申请日:
2014.05.21
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.
