Jeffrey Schwartz,Christopher A. Traina,Thomas Joseph Dennes
申请号：
US12489242
公开号：
US08372435B2
申请日:
2009.06.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film: the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle-cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.
