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Anticorps anti-alpha v bêta 6 et utilisations associées
专利权人:
Biogen Idec MA Inc.
发明人:
申请号:
EP11008293.0
公开号:
EP2458012A1
申请日:
2006.06.10
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
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中国工程科技知识中心
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