Violette, Shelia M.,Koopman, Louise A.,Simon, Kenneth J.,Weinreb, Paul H.,Van Vlijmen, Herman,Saldanha, Jose,Lugovskoy, Alexey A.
申请号：
AU2012258386
公开号：
AU2012258386A1
申请日:
2012.11.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012258386A120121213.pdf#####Abstract The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v6 integrins which comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to phannaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti-v6 antibodies. The invention also relates to the identification of differential expression of the integrin av36 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tunor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin av86.
