VIOLETTE, SHELIA,KOOPMAN, LOUISE A.,SIMON, KENNETH J.,WEINREB, PAUL H.,VAN VLIJMEN, HERMAN,SALDANHA, JOSE,LUGOVSKOY, ALEXEY A.
申请号：
CA2614183
公开号：
CA2614183C
申请日:
2006.07.10
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention is in the fields of cell biology, immunology andoncology. Specifically, the invention relates to humanized antibodies thatrecognizes v 6 integrins which comprises a variable region of nonhuman originand at least -a portion of an immunoglobulin of human origin. The inventionalso relates to processes for their preparation, to pharmaceuticalcompositions comprising them and to methods of treating various diseases byadministering humanized anti- v 6 antibodies. The invention also relates tothe identification of differential expression of the integrin av~6 on thesurfaces of tumor cells and tissues, the use of this differential expressionin determining the metastatic potential of tumor cells, and methods ofdiagnosis and treatment/prevention of tumor metastasis and for elimination ofresidual metastatic tumor cells using ligands, particularly antibodies, thatbind to integrin av~6.
