Pusan National University Industry - University Cooperation Foundation
发明人:
MOON, Hyung Ryong,CHUNG, Hae Young,AN, Hye Jin,SON, Su Jin,KIM, Do Hyun
申请号：
EP18787262
公开号：
EP3613735A4
申请日:
2018.04.18
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a SIRT 1 activator and medical use thereof and in the present invention, a novel SIRT 1 activator compound based on benzo[d]furan or a benzo[d]oxazole backbone, a crystalline form thereof, a hydrate thereof, or a salt thereof was prepared, and that the compound has obesity, insulin resistance and dyslipidemia improvement effect, fatty liver improvement effect, cell aging protection, oxidative stress protection and yeast life extension effect, collagen synthesis and wrinkle improvement effect, was confirmed. Therefore, the novel SIRT 1 activator compound having the above-mentioned effect is usefully used as a pharmaceutical composition for preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, etc., or liver diseases including alcoholic or non-alcoholic fatty liver, fatty hepatitis, etc., a cosmetic composition for preventing or improving wrinkles, a health food composition for improving cell aging or extending lifespan, and the like.
