INHIBITEURS ACYL-PIPÉRIDINIQUES DE L'ÉPOXYDE HYDROLASE SOLUBLE

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专利权人:

The Regents of the University of California

发明人:

申请号：

EP13743624.2

公开号：

EP2809650B1

申请日:

2013.02.01

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/