This vaccine provides the recombinant vaccine of Lawsonia in cells, which is based on the synthesis, synthesis and synthesis of synthetic variant membrane protein and invasive protein. In addition, the synthetic nucleon sequences are also transmitted, and the expression bands of these protein variants, recombinant proteins, protein synthetic antigens, transformation of cells and methods of producing antigens are coded. To show its antigenicity and protective potential to prevent the intracellular Lawson pathogen.La presente provee una vacuna recombinante contra Lawsonia intracellularis basada en una variante quimérica sintética recombinante de proteínas de membrana e invasinas de dicha bacteria. Adicionalmente, se divulga secuencias nucleotídicas sintéticas que codifican dichas variantes proteicas, proteínas recombinantes como tales, un casete de expresión de dichos antígenos sintéticos proteicos, una célula transformada y un método para la producción de dichos antígenos, demostrando su antigenicidad y potencial protectivo frente al patógeno Lawsonia intracellularis.
