您的位置: 首页 > 农业专利 > 详情页

DRUG-FREE FORMULATION PROTECTED FROM APPLICATION FOR OPIOID-SENSITIVE SENSITIVES
专利权人:
ГРЮНЕНТАЛЬ ГМБХ (DE)
发明人:
БАРТОЛОМЭУС Иоганнес (DE),ГАЙССЛЕР Аня (DE),БЕРТРАМ Ульрике (DE),ГРИССМАНН Корнелия (DE)
申请号:
RU2012106166/15
公开号:
RU2012106166A
申请日:
2010.07.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A thermoformed pharmaceutical dosage form having a tensile strength of at least 300 N and containing an opioid (A) is a physiologically free acid (B) free in an amount of from 0.001 to 5.0 wt. %, based on the total weight of the pharmaceutical dosage form, and polyalkylene oxide (C) having a weight average molecular weight M of at least 500,000 g / mol. 2. The pharmaceutical dosage form according to claim 1, wherein the acid (B) is multicarboxylic acid. The pharmaceutical dosage form according to claim 2, wherein the multicarboxylic acid is selected from the group consisting of maleic acid, fumaric acid, glutaric acid, malonic acid and citric acid. The pharmaceutical dosage form according to claim 1, wherein the acid content (B) is in the range of 0.005 to 2.5% by weight, based on the total weight of the pharmaceutical dosage form. The pharmaceutical dosage form according to claim 1, which contains polyalkylene glycol, where the ratio of the specific gravity of the polyalkylene oxide to polyalkylene glycol is in the range of 4.2 ± 2: 1.6. Pharmaceutical dosage form in accordance with claim 1, which contains an antioxidant. The pharmaceutical dosage form according to claim 6, wherein the antioxidant is α-tocopherol. A pharmaceutical dosage form according to claim 6 or 7, wherein the antioxidant content is in the range of 0.001 to 5.0% by weight, based on the total weight of the pharmaceutical dosage form. The pharmaceutical dosage form in accordance with claim 1, where after storage for1. Термоформованная фармацевтическая лекарственная форма, имеющая предел прочности на разрыв, составляющий, по крайней мере, 300 Н и содержащая- опиоид (А),- свободную физиологически приемлемую кислоту (В) в количестве, которое составляет от 0,001 до 5,0 мас.%, из расчета общей массы фармацевтической лекарственной формы, и- полиалкиленоксид (С), имеющий среднемассовую молекулярную массу М, составляющую, по крайней мере, 500000 г/моль.2. Фармацевтическая лекарственная форма в соответ
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充