PSMA DEVELOPMENT COMPANY, L.L.C.;AMGEN FREMONT INC.
发明人:
MADDON, PAUL J.,DONOVAN, GERALD P.,OLSON, WILLIAM C.,SCHUELKE, NORBERT,GARDNER, JASON,MA, DANGSHE,KANG, JASPAL S.,GREEN, LARRY
申请号：
CA2464239
公开号：
CA2464239C
申请日:
2002.10.23
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention includes antibodies or antigen-binding fragments thereof whichbind specifically to conformational epitopes on the extracellular domain ofPSMA, compositions containing one or a combination of such antibodies orantibodies or antigen-binding fragments thereof, hybridoma cell lines thatproduce the antibodies, and methods of using the antibodies or antigen-bindingfragments thereof for cancer diagnosis and treatment. The invention alsoincludes oligomeric forms of PSMA proteins, compositions comprising themultimers, and antibodies that selectively bind to the multimers.
