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2,3-BENZODIAZEPINES
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
SIEGEL, STEPHAN,BAURLE, STEFAN,CLEVE, ARWED,HAENDLER, BERNARD,FERNANDEZ-MONTALVAN, AMAURY ERNESTO,MONNING, URSULA,KRAUSE, SABINE,LEJEUNE, PASCALE,SCHMEES, NORBERT,BUSEMANN, MATTHIAS,HOLTON, SIMON,KUHN
申请号:
PH12015500323
公开号:
PH12015500323A1
申请日:
2015.02.13
申请国别(地区):
PH
年份:
2015
代理人:
摘要:
What are described are BET protein-inhibitory, in particular BRD4-inhibitory, 2,3-benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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