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2,3-benzodiazepines
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
Stephan Siegel,Stefan Bäurle,Arwed Cleve,Bernard Haendler,Amaury Ernesto Fernandez-Montalvan,Ursula Mönning,Sabine Krause,Pascale Lejeune,Norbert Schmees,Matthias Busemann,Simon Holton,Joachim Kuhnke
申请号:
US14421994
公开号:
US09890147B2
申请日:
2013.08.13
申请国别(地区):
US
年份:
2018
代理人:
摘要:
What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I)in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumor disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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