FINLAY, MAURICE RAYMOND VERSCHOYLE,NISSINK, JOHANNES WILHELMUS MARIA,CHARLES, MARK DAVID
申请号：
CA3005495
公开号：
CA3005495A1
申请日:
2016.11.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A compound of Formula (I) or a pharmaceutically acceptable salt thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl； R1 can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, or 3,3- difluoroazetidin-1-yl； R2 can be hydrogen or fluoro； R3 can be hydrogen or methoxy； and R4 can be methoxy, ethoxy, or methoxymethyl； provided that when R1 is hydrogen, methoxy or trifluoromethoxy, then R3 is not hydrogen, and/or R4 is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
