FINLAY, Maurice Raymond Verschoyle,NISSINK, Johannes Wilhelmus Maria,CHARLES, Mark David
申请号：
CO2018006928
公开号：
CO2018006928A2
申请日:
2018.06.29
申请国别(地区):
CO
年份:
2018
代理人:
摘要：
A compound of Formula (I):or a pharmaceutically acceptable salt thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl R1 can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, or 3,3-difluoroazetidin-1-yl R2 can be hydrogen or fluoro R3 can be hydrogen or methoxy and R4 can be methoxy, ethoxy, or methoxymethyl provided that when R1 is hydrogen, methoxy or trifluoromethoxy, then R3 is not hydrogen, and/or R4 is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
