Michel Leonetti,Patricia Lamourette,Herve Volland,Alexandra Savatier,Anne Wijkhuisen
申请号：
US14647151
公开号：
US09816072B2
申请日:
2013.11.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells a method for producing antigen-specific human antibodies derived from said in vitro immunization method.
