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הרכב רוקחי המכיל תצמיד של פולאט–פלואורסצאין
专利权人:
PURDUE RESEARCH FOUNDATION
发明人:
申请号:
IL21324011
公开号:
IL213240A
申请日:
2011.05.31
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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