Ali Hussain,Linda Cahalan,Greg Johnson,Mark Gartner,Patrick Cahalan,Brian J. Fill,Jeffrey W. Speakman
申请号：
US15640873
公开号：
US20180125620A1
申请日:
2017.07.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device b) cleaning the tubular polyolefin substrate c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
