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Tau imaging probe
专利权人:
CLINO Ltd.
发明人:
Kudo, Yukitsuka,Furumoto, Syozo,Okamura, Nobuyuki
申请号:
AU2011321310
公开号:
AU2011321310A1
申请日:
2011.10.28
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
One of the purposes of the present invention is to provide a probe for imaging a protein having a β-sheet structure for the purpose of diagnosing conformation diseases, particularly diseases in which the accumulation of tau protein in the brain is observed as the main characteristic symptom (tauopathy) such a Alzheimers disease.Another one of the purposes of the present invention is to provide a compound which has high specificity to tau, enables the imaging of tau with good sensitivity, has high brain migration properties, is accumulated in bones in a minute amount or is not accumulated in bones, and has low toxicity or does not have toxicity.The present invention achieves the above-mentioned purposes by providing a compound represented by formula (I) (wherein A, R
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