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TAU IMAGING PROBE
专利权人:
发明人:
KUDO YUKITSUKA,FURUMOTO SYOZO,OKAMURA NOBUYUKI
申请号:
IN3985/CHENP/2013
公开号:
IN2013CN03985A
申请日:
2013.05.21
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
123One of the purposes of the present invention is to provide a probe for imaging a protein having a sheet structure for the purpose of diagnosing conformation diseases particularly diseases in which the accumulation of tau protein in the brain is observed as the main characteristic symptom (tauopathy) such a Alzheimer s disease. Another one of the purposes of the present invention is to provide a compound which has high specificity to tau enables the imaging of tau with good sensitivity has high brain migration properties is accumulated in bones in a minute amount or is not accumulated in bones and has low toxicity or does not have toxicity. The present invention achieves the above mentioned purposes by providing a compound represented by formula (I) (wherein A R R R and others are as defined in the description) or a pharmaceutically acceptable salt or solvate thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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