ANTIBODY AND NUCLEIC ACID MOLECULES

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专利权人:

NOVARTIS AG

发明人:

JAMES BURNIE,PHILIPP WECHNER

申请号：

BRPI0810827

公开号：

BRPI0810827A2

申请日:

2008.04.24

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

An scFv peptide comprising a VH domain and a VL domain linked by an amino acid spacer is disclosed. The VH domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 64. The VL domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 66. The scFv peptide also comprises the substitution or deletion of an amino acid in the VH domain at the position corresponding to C28.

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