MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
RODRIGUEZ, MOSES,MILLER, DAVID J.,PEASE, LARRY R.
申请号：
ES10180618
公开号：
ES2531552T3
申请日:
2000.05.30
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A human monoclonal antibody, monomer or active fragment thereof, characterized by its ability to bind oligodendrocytes, or a synthetic antibody derived therefrom and which has the ability to bind oligodendrocytes, with the following characteristics: (a) capable of inducing remyelination； (b) capable of promoting cell proliferation of glial cells； and (c) capable of promoting Ca2 + signaling in oligodendrocytes； and which: comprises a variable region of the heavy chain having the sequences of the CDR1, CDR2 and CDR3 region as set forth in Figure 17, and comprises a variable region of the light chain having the sequences of the CDR1, CDR2 region and CDR3 as set forth in Figure 18； it comprises a variable region of the heavy chain having the sequences of the region CDR1, CDR2 and CDR3 as set forth in Figure 19, and comprises a variable region of the light chain having the sequences of the region CDR1, CDR2 and CDR3 as It is set out in Figure 20； or comprises a variable region of the heavy chain having the sequences of the CDR1, CDR2 and CDR3 region as set forth in Figure 27, and comprising a variable region of the light chain having the sequences of the CDR1, CDR2 and CDR3 region as set out in Figure 28.Un anticuerpo monoclonal humano, monómero o fragmento activo del mismo, caracterizado por su capacidad para unirse a oligodendrocitos, o un anticuerpo sintético derivado del mismo y que tiene la capacidad de unirse a oligodendrocitos, con las siguientes características: (a) capaz de inducir la remielinización； (b) capaz de promover la proliferación celular de células gliales； y (c) capaz de promover la señalización de Ca2+ en oligodendrocitos； y que: comprende una región variable de la cadena pesada que tiene las secuencias de la región CDR1, CDR2 y CDR3 como se expone en la Figura 17, y comprende una región variable de la cadena ligera que tiene las secuencias de la región CDR1, CDR2 y CDR3 como se expone en la Figura 18； comprende una región variable de la cadena pesa
