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STABLE FORMULATIONS OF ANTI-CTLA4 ANTIBODIES ALONE AND IN COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF
专利权人:
Merck Sharp &; Dohme Corp.
发明人:
Soumendu Bhattacharya,Chakravarthy Nachu Narasimhan,Manoj K. Sharma,Xiaoyu Yang,Arnab De,Rubi Burlage,Jason K. Cheung
申请号:
US16609671
公开号:
US20200262922A1
申请日:
2018.05.01
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention relates to stable formulations comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4), optionally further containing an anti-human programmed death receptor 1 (PD-1) antibody or antigen binding fragment thereof. Also provided are methods of treating various cancers and chronic infections with the formulations of the invention.
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