ANTIBODIES WITH ENGINEERED IGG FC DOMAINS

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专利权人:

发明人:

George Georgiou,William Kelton,Nishant Mehta

申请号：

US14437544

公开号：

US20150266960A1

申请日:

2013.08.30

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/