A pulse diagnosis measurement device comprises a sensing device, for sensing a blood pressure wave of an organism, to generate a pulse signal； a pulse-holding device, for applying a pressure on a pulse of the organism, wherein the pulse-holding device has an elasticity coefficient, the elasticity coefficient is corresponding to a frequency of a harmonic of the blood pressure wave, and the harmonic is an integer harmonic or a fractional harmonic； and a processing device, for generating pulse diagnosis information of the harmonic according to the pulse signal.
