A method of pulse diagnosis measurement comprises applying a pressure to a pulse of an organism via a pulse-holding device； sensing a blood pressure wave of the organism via a sensing device, to generate a first pulse signal； computing a difference between a maximum value and a minimum value of each blood pressure wave of the first pulse signal； continuing adjusting the pressure of the pulse-holding device until the difference is not increased, at which time the pressure has a most suitable pressure value； and sensing the blood pressure wave according to the most suitable pressure value, to generate a second pulse signal.
