The present invention provides the use of menthol or menthol isomers for the preparation of an external composition for improving neurodegenerative disease or stroke. The neurodegenerative disease is caused by damage and degeneration of neurons in the brain or insufficient dopamine in the brain ； The external composition is a product made through a patch, liquid, cream, oil, powder, gel, spray or other combination methods or made into a product covering the limbs and applied to the skin, as described above The products covering the limbs are extended design parts or layers of gloves, foot covers, socks, and clothing, which can ensure continuous contact between the skin and menthol； the present invention also provides menthol or menthol isomers for the preparation of improved factors Use of a topical composition for brain neuron damage and degradation, brain dopamine deficiency, diseases or symptoms caused by stroke.本發明提供一種薄荷醇或薄荷醇異構物用於製備改善神經退化症或中風的外用組合物的用途，所述之神經退化症為腦部神經元受損退化或腦部多巴胺不足所導致的；所述外用組合物係透過貼布、液狀、膏狀、油狀、粉狀、凝膠、噴劑或其他組合方式製作成之產品或製作成包覆四肢之製品，施用於皮膚，前述包覆四肢之製品為手套、腳套、襪子、衣物之延伸設計部位或層狀物，可確保皮膚與薄荷醇的持續接觸；本發明更提供薄荷醇或薄荷醇異構物用於製備改善因腦部神經元受損退化、因腦部多巴胺不足、因中風所導致之疾病或症狀的外用組合物的用途。
