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CONDENSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE
专利权人:
LIMITED;DAJITI SANKIO KOMPANI
发明人:
TAKAKhASI Khisasi (JP),ТАКАХАСИ Хисаси (JP),KOMORIJA Satosi (JP),КОМОРИЙА Сатоси (JP),KITAMURA Takakhiro (JP),КИТАМУРА Такахиро (JP),ODAGIRI Takasi (JP),ОДАГИРИ Такаси (JP),INAGAKI Khiroaki (JP),ИНАГА,TAKAKHASI KHISASI,KOMORIJA SATOSI,KITAMURA TAKAKHIRO,ODAGIRI TAKASI,INAGAKI KHIROAKI,ИНАГАКИ Хироаки (JP),TSUDA TOS
申请号:
RU2009129975/04
公开号:
RU0002443698C2
申请日:
2007.12.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I), and a salt or hydrate thereof:,in which R1 denotes a hydrogen atom; R2 denotes a hydrogen atom; R3 and R4 independently denote a hydrogen atom; R5 denotes a hydrogen atom or a fluorine atom; R6 and R7, together with carbon atoms to which they are bonded, form a 5- or 6-member cyclic structure, where the cyclic structure is a partial structure which, together with a pyrrolidine ring, forms a condensed cyclic (bicyclic) structure, the 5- or 6-member cyclic structure can contain an oxygen atom as a ring atom, R5 can be a methylene group which, together with R6, forms a 3-member condensed cyclic structure; and Q is a partial structure of formula (II):,in which R8 denotes a 1,2-cis-2-halogencyclopropyl group, a cyclopropyl group or a 6-amino-3,5-difluoropyridin-2-yl group; R9 denotes a hydrogen atom; R10 denotes a hydrogen atom; R11 denotes a hydrogen atom; XI denotes a fluorine or hydrogen atom; A1 denotes a nitrogen or partial structure of formula (III):,in which X2 is a methyl group, an ethyl group, a methoxy group or a chlorine atom, or X2 and R8, together with their coupling part of the parent skeleton, form a cyclic structure, such that Q denotes a partial structure of formula , in which Y0 denotes a methyl group or a pre-methyl group, and X1, R9, R10, R11 assume values given above. The invention also describes a medicinal agent based on said compound, having antibacterial activity, an antibacterial agent and a therapeutic agent for treating infections.EFFECT: novel compounds are obtained and described, which have strong antibacterial activity not only on gram-negative bacteria, but gram-positive cocci as well, which have low sensitivity to quinolone antibacterial agents, and which demonstrate high safety and excellent pharmacokinetic properties.18 cl, 61 exИзобретение относится к соединению, представленному следующей формулой (I), к его соли или гидрату:в которой R1 обозначает атом водор
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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